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Thoas Fioretos

Thoas Fioretos

Research team manager

Thoas Fioretos

Threshold-free high-power methods for the ontological analysis of genome-wide gene expression studies

Author

  • Björn Nilsson
  • Petra Johnels
  • Mikael Johansson
  • Sven Nelander
  • Thoas Fioretos

Summary, in English

Ontological analysis facilitates microarray data interpretation. We describe new ontological analysis methods which, unlike existing approaches, are threshold-free and statistically powerful. We perform extensive evaluations and introduce a new concept, detection spectra, to characterize methods. We show that different ontological analysis methods exhibit distinct detection spectra, and that it is critical to account for this diversity. Our results argue strongly against the continued use of existing methods, and provide directions towards an enhanced approach.

Department/s

  • Department of Laboratory Medicine
  • Division of Clinical Genetics

Publishing year

2007

Language

English

Publication/Series

Genome Biology

Volume

8

Issue

5

Document type

Journal article

Publisher

BioMed Central (BMC)

Topic

  • Medical Genetics

Status

Published

ISBN/ISSN/Other

  • ISSN: 1474-7596