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Thoas Fioretos

Thoas Fioretos

Research team manager

Thoas Fioretos

An improved method for detecting and delineating genomic regions with altered gene expression in cancer

Author

  • Björn Nilsson
  • Mikael Johansson
  • Anders Heyden
  • Sven Nelander
  • Thoas Fioretos

Summary, in English

ABSTRACT: Genomic regions with altered gene expression are a characteristic feature of cancer cells. We present a novel method for identifying such regions in gene expression maps. This method is based on total variation (TV) minimization, a classical signal restoration technique. In systematic evaluations, we show that our method combines top-notch detection performance with an ability to delineate relevant regions without excessive over-segmentation, making it a significant advance over existing methods. Software (Rendersome) is provided.

Department/s

  • Division of Hematology and Clinical Immunology
  • Hematogenomics
  • Division of Clinical Genetics

Publishing year

2008

Language

English

Publication/Series

Genome Biology

Volume

9

Issue

1

Document type

Journal article

Publisher

BioMed Central (BMC)

Topic

  • Medical Genetics

Status

Published

Research group

  • Hematogenomics

ISBN/ISSN/Other

  • ISSN: 1474-7596