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Thoas Fioretos

Thoas Fioretos

Research team manager

Thoas Fioretos

Precisionsmedicin standard vid flera hematologiska sjukdomar

Precision diagnostics and therapy in hematological malignancies

Author

  • Eva Hellström Lindberg
  • Lucia Cavelier
  • Jörg Cammenga
  • Per Ola Andersson
  • Thoas Fioretos
  • Richard Rosenquist

Summary, in English

Precision diagnostics and therapy have been implemented rather early in clinical hematology due to the easy accessibility of blood and bone marrow, allowing not only for consecutive genetic analysis at diagnosis, remission and relapse, but also for culturing these cells and testing new drugs in vitro. One contributing factor has also been the relatively low number of »driver« mutations in hematologic malignancies and that some of them are gain of function mutations that are relatively easy to target by drugs. Examples of this development are ABL1-, JAK2-, and FLT3-inhibitors for the treatment of chronic myeloid leukemia, myeloproliferative neoplasms, and acute myeloid leukemia, respectively. More recently, gene panel sequencing has been introduced in clinical routine to identify genetic alterations with diagnostic, prognostic and predictive impact, and more sensitive techniques to monitor minimal residual disease are emerging. Whole genome and transcriptome sequencing are currently evaluated as the next diagnostic tool. Finally, a large number of targeted therapies are currently under development and/or undergoing clinical trials.

Department/s

  • Division of Clinical Genetics
  • Translational Genomic and Functional Studies of Leukemia
  • LUCC: Lund University Cancer Centre

Publishing year

2021-05

Language

Swedish

Publication/Series

Lakartidningen

Volume

118

Document type

Journal article

Publisher

Swedish Medical Association

Topic

  • Hematology

Status

Published

Research group

  • Translational Genomic and Functional Studies of Leukemia

ISBN/ISSN/Other

  • ISSN: 0023-7205