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Thoas Fioretos

Thoas Fioretos

Research team manager

Thoas Fioretos

t(3;21)(q26;q22) with AML1 rearrangement in a de novo childhood acute monoblastic leukaemia

Author

  • Bertil Johansson
  • Thoas Fioretos
  • Stanislaw Garwicz
  • Sverre Heim
  • Felix Mitelman

Summary, in English

t(3;21)(q26;q22) is a recurrent chromosomal abnormality in Philadelphia-positive chronic myeloid leukaemia in blast crisis and in treatment-related myelodysplastic syndrome and acute myeloid leukaemia. The molecular consequences of the t(3;21) are presently being unravelled; various transcripts between the AML1 gene in 21q22 and several unrelated genes, i.e. EAP, EVI1 and MDS1, in 3q26 are generated, resulting in the formation of a chimaeric transcription factor. The t(3;21) has only rarely been described in de novo leukaemias and never before in an acute leukaemia in a child. We here present the clinical, cytogenetic and molecular genetic findings in a boy with a de novo acute monoblastic leukaemia with t(3;21)(q26;q22) and AML1 rearrangement.

Department/s

  • Division of Clinical Genetics
  • Paediatrics (Lund)

Publishing year

1996

Language

English

Pages

429-431

Publication/Series

British Journal of Haematology

Volume

92

Issue

2

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Hematology

Keywords

  • childhood
  • acute leukaemia
  • translocation
  • AML1

Status

Published

ISBN/ISSN/Other

  • ISSN: 0007-1048