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Thoas Fioretos

Thoas Fioretos

Research team manager

Thoas Fioretos

The incidence of trisomy 8 as a sole chromosomal aberration in myeloid malignancies varies in relation to gender, age, prior iatrogenic genotoxic exposure, and morphology

Author

  • Kajsa Paulsson
  • Torbjörn Säll
  • Thoas Fioretos
  • Felix Mitelman
  • Bertil Johansson

Summary, in English

Although trisomy 8 as a sole change is one of the most common chromosomal abnormalities in myeloid malignancies, it is largely unknown if the incidence of this aberration is influenced by other factors of clinical importance. In the present study, the frequencies of isolated +8 in relation to gender, age, previous treatment with chemo- or radiotherapy, and morphologic subtype were ascertained in published, as well as in our own unpublished, cases of acute myeloid leukemia (AML; n=4,246), myelodysplastic syndromes (MDS; n=1,817), and chronic myeloproliferative disorders (MPD; n=530). The frequencies of +8 were higher in MDS and MPD than in AML (7.5% vs. 5.6%; P<0.01) and varied among the morphologic subtypes of AML and MDS (P<0.001 and P<0.05, respectively). Trisomy 8 was more common in women than in men with MPD (11% vs. 5.1%; P<0.05). Furthermore, the frequencies of +8 were higher in de novo AML and MDS than in treatment-related cases (6.0% vs. 2.8%; P<0.01 and 8.6% vs. 1.5%; P<0.001, respectively). The incidence also varied significantly with age in AML (P<0.001), being more common in elderly patients. Although the causes for this frequency heterogeneity remain to be elucidated, possible explanations may include different environmental exposures affecting the origin of +8 in AML, MDS, and MPD and the presence of different underlying cryptic primary aberrations.

Department/s

  • Division of Clinical Genetics
  • MEMEG
  • Evolutionary Genetics

Publishing year

2001

Language

English

Pages

160-165

Publication/Series

Cancer Genetics and Cytogenetics

Volume

130

Issue

2

Document type

Journal article

Publisher

Elsevier

Topic

  • Medical Genetics

Status

Published

Research group

  • Evolutionary Genetics

ISBN/ISSN/Other

  • ISSN: 0165-4608