Genetic variation at RAB3GAP2 and its role in exercise-related adaptation and recovery

Summary, in English

Skeletal muscle fiber composition and capillary density influence physical performance and whole-body metabolic properties. ~45% of the variance in fiber type is heritable, which motivated us to perform a genome-wide association study of skeletal muscle histology from 656 Swedish men. Four independent variants were associated (p

• Author: Kristoffer Ström; Nikolay Oskolkov; Tugce Karaderi; Sebastian Kalamajski; Ola Ekström; Eri Miyamoto-Mikami; Claes Ladenvall; Ellen Kakulidis; Steven Reid; Anna-Maria Dutius Andersson; Dmytro Kryvokhyzha; Enming Zhang; Joao Fadista; Motoyuki Iemitsu; Anubha Mahajan; Emma Ahlqvist; Rashmi Prasad; Kay Pruefer; Maria Sabater-Lleal; Nicholas L Smith; Abbas Dehghan; Lars Lind; Kerry McGawley; Andrew Morris; Mikko Lehtovirta; Lukasz Szczerbiński; Adam Kretowski; Guan Wang; Yannis Pitsiladis; Alejandro Santos-Lozano; Alejandro Lucia; Noriyuki Fuku; Hans Christer Holmberg; Leif Groop; Maria F Gomez; Karl-Fredrik Eriksson; Kristian Pietras; Cecilia Lindgren; Paul Franks; Ola Hansson
• Department/s: EXODIAB: Excellence of Diabetes Research in Sweden; Translational Muscle Research; Bioinformatics; Molecular Cell Biology; Genetic and Molecular Epidemiology; Experimental oncology; Diabetic Complications; NanoLund: Centre for Nanoscience; Diabetes - Islet Patophysiology; Vascular Diseases - Clinical Research; Division of Translational Cancer Research; EpiHealth: Epidemiology for Health
• Publishing year: 2021-07-16
• Language: English
• Pages: 1-16
• Links: http://dx.doi.org/10.21203/rs.3.rs-701652/v1
• Document type: Preprint
• Publisher: Research Square
• Topic: Physiology
• Status: Published
• Research group: Genomics, Diabetes and Endocrinology; Bioinformatics; Genetic and Molecular Epidemiology; Experimental oncology; Diabetic Complications; Diabetes - Islet Patophysiology; Vascular Diseases - Clinical Research