Kristian Pietras
Research team manager
Cellular plasticity in the breast cancer ecosystem
Author
Summary, in English
The complex interplay between genetically diverse tumor cells and their microenvironment significantly influences cancer progression and therapeutic responses. This review highlights recent findings on cellular plasticity and heterogeneity within the breast cancer ecosystem, focusing on the roles of cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs). We discuss evidence suggesting that breast cancer cells exhibit phenotypic plasticity driven by both intrinsic genetic factors and external microenvironmental cues, impacting treatment responses and disease recurrence. Moreover, single-cell RNA sequencing studies reveal diverse subtypes of CAFs and TAMs, each with distinct functional gene expression programs and spatial organization within the tumor microenvironment. Understanding the hierarchical relationships and niche cues governing cellular phenotypes offers new opportunities for targeted therapeutic interventions. By elucidating the organizational principles of the tumor ecosystem, future therapies may target phenotypic states or entire cellular niches, advancing precision medicine approaches in breast cancer treatment.
Department/s
- LUCC: Lund University Cancer Centre
- Experimental oncology
- Division of Translational Cancer Research
Publishing year
2024
Language
English
Publication/Series
Upsala Journal of Medical Sciences
Volume
129
Document type
Journal article review
Publisher
Taylor & Francis
Topic
- Cancer and Oncology
Keywords
- cancer-associated fibroblasts
- macrophages
- Tumor microenvironment
- tumor-initiating cells
Status
Published
Research group
- Experimental oncology
ISBN/ISSN/Other
- ISSN: 0300-9734