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Håkan Axelson

Håkan Axelson

Research team manager

Håkan Axelson

Human achaete-scute homologue 1 (HASH-1) is downregulated in differentiating neuroblastoma cells

Author

  • H Söderholm
  • Eva Örtoft
  • Irja Johansson
  • June Ljungberg
  • Christer Larsson
  • Håkan Axelson
  • Sven Påhlman

Summary, in English

The mammalian achaete-scute homologue, MASH-1, is crucial for early development of the sympathetic nervous system and is transiently expressed in sympathetic neuroblasts during embryogenesis. Here we report that the human homologue (HASH-1) was expressed in all analyzed cell lines (6/6) derived from the sympathetic nervous system tumor neuroblastoma. The majority of small-cell lung carcinoma (4/5) cell lines tested expressed HASH-1, while other nonneuronal/non-neuroendocrine cell lines were negative. Induced differentiation of neuroblastoma cells resulted in HASH-1 downregulation. This occurred concomitant with induction of neurite outgrowth and expression of the neuronal marker genes GAP-43 and neuropeptide Y. Constitutive expression of exogenous HASH-1 did not alter the capacity of the neuroblastoma cells to differentiate in response to differentiation-inducing agents. It is concluded that moderate HASH-1 expression does not compromise the capacity of these cells to differentiate.

Department/s

  • Genomics, Diabetes and Endocrinology
  • Department of Translational Medicine

Publishing year

1999

Language

English

Pages

557-563

Publication/Series

Biochemical and Biophysical Research Communications

Volume

256

Issue

3

Document type

Journal article

Publisher

Elsevier

Topic

  • Biological Sciences

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1090-2104