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Håkan Axelson

Håkan Axelson

Research team manager

Håkan Axelson

Soft Drink and Juice Consumption and Renal Cell Carcinoma Incidence and Mortality in the European Prospective Investigation into Cancer and Nutrition


  • Alicia K Heath
  • Joanna L Clasen
  • Nick P Jayanth
  • Mazda Jenab
  • Anne Tjønneland
  • Kristina Elin Nielsen Petersen
  • Kim Overvad
  • Bernard Srour
  • Verena Katzke
  • Manuela M Bergmann
  • Matthias B Schulze
  • Giovanna Masala
  • Vittorio Krogh
  • Rosario Tumino
  • Alberto Catalano
  • Fabrizio Pasanisi
  • Magritt Brustad
  • Karina Standahl Olsen
  • Guri Skeie
  • Leila Luján-Barroso
  • Miguel Rodríguez-Barranco
  • Pilar Amiano
  • Carmen Santiuste
  • Aurelio Barricarte Gurrea
  • Håkan Axelson
  • Stina Ramne
  • Börje Ljungberg
  • Eleanor L Watts
  • Inge Huybrechts
  • Elisabete Weiderpass
  • Elio Riboli
  • David C Muller

Summary, in English

BACKGROUND: Renal cell carcinoma (RCC) accounts for more than 80% of kidney cancers in adults, and obesity is a known risk factor. Regular consumption of sweetened beverages has been linked to obesity and several chronic diseases, including some types of cancer. It is uncertain whether soft drink and juice consumption is associated with risk of RCC. We investigated the associations of soft drink and juice consumption with RCC incidence and mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC).

METHODS: A total of 389,220 EPIC participants with median age of 52 years at recruitment (1991-2000) were included. Cox regression yielded adjusted HRs and 95% confidence intervals (CI) for RCC incidence and mortality in relation to intakes of juices and total, sugar-sweetened, and artificially sweetened soft drinks.

RESULTS: A total of 888 incident RCCs and 356 RCC deaths were identified. In models including adjustment for body mass index and energy intake, there was no higher risk of incident RCC associated with consumption of juices (HR per 100 g/day increment = 1.03; 95% CI, 0.97-1.09), total soft drinks (HR = 1.01; 95% CI, 0.98-1.05), sugar-sweetened soft drinks (HR = 0.99; 95% CI, 0.94-1.05), or artificially sweetened soft drinks (HR = 1.02; 95% CI, 0.96-1.08). In these fully adjusted models, none of the beverages was associated with RCC mortality (HR, 95% CI per 100 g/day increment 1.06, 0.97-1.16; 1.03, 0.98-1.09; 0.97, 0.89-1.07; and 1.06, 0.99-1.14, respectively).

CONCLUSIONS: Consumption of juices or soft drinks was not associated with RCC incidence or mortality after adjusting for obesity.

IMPACT: Soft drink and juice intakes are unlikely to play an independent role in RCC development or mortality.


  • LUCC: Lund University Cancer Centre
  • Department of Laboratory Medicine
  • Kidney cancer research group
  • Division of Translational Cancer Research
  • Nutrition Epidemiology
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year







Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology





Document type

Journal article


American Association for Cancer Research


  • Nutrition and Dietetics
  • Cancer and Oncology
  • Public Health, Global Health, Social Medicine and Epidemiology



Research group

  • Kidney cancer research group
  • Nutrition Epidemiology


  • ISSN: 1538-7755