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The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels.

Author:
  • Helena Fritz
  • Anna Gustafsson
  • Börje Ljungberg
  • Yvonne Ceder
  • Håkan Axelson
  • Björn Dahlbäck
Publishing year: 2015
Language: English
Publication/Series: PLoS ONE
Volume: 10
Issue: 8
Document type: Journal article
Publisher: Public Library of Science

Abstract english

High expression of the receptor tyrosine kinase Axl is associated with poor prognosis in patients with Renal Cell Carcinoma (RCC), the most common malignancy of the kidney. The miR-34a has been shown to directly regulate Axl in cancer cells. The miR-34a is a mediator of p53-dependent tumor suppression, and low expression of miR-34a has been associated with worse prognosis in several cancers. Our aim was to elucidate whether miR-34a or the other members of the miR-34 family (miR-34b/c) regulate Axl in RCC.

Keywords

  • Cancer and Oncology

Other

Published
  • Clinical Chemistry, Malmö
  • ISSN: 1932-6203
Håkan Axelson
E-mail: hakan [dot] axelson [at] med [dot] lu [dot] se

Professor

Division of Translational Cancer Research

+46 46 222 64 34

MV 404 A31A2

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