Håkan Axelson
Research team manager
The STRIPAK Complex Regulates Response to Chemotherapy Through p21 and p27
Author
Summary, in English
The STRIPAK complex has been linked to a variety of biological processes taking place during embryogenesis and development, but its role in cancer has only just started to be defined. Here, we expand on previous work indicating a role for the scaffolding protein STRIP1 in cancer cell migration and metastasis. We show that cell cycle arrest and decreased proliferation are seen upon loss of STRIP1 in MDA-MB-231 cells due to the induction of cyclin dependent kinase inhibitors, including p21 and p27. We demonstrate that p21 and p27 induction is observed in a subpopulation of cells having low DNA damage response and that the p21high/γH2AXlow ratio within single cells can be rescued by depleting MST3&4 kinases. While the loss of STRIP1 decreases cell proliferation and tumor growth, cells treated with low dosage of chemotherapeutics in vitro paradoxically escape therapy-induced senescence and begin to proliferate after recovery. This corroborates with already known research on the dual role of p21 and indicates that STRIP1 also plays a contradictory role in breast cancer, suppressing tumor growth, but once treated with chemotherapeutics, allowing for possible recurrence and decreased patient survival.
Department/s
- LUCC: Lund University Cancer Centre
- Division of Translational Cancer Research
- Cancer and matrix remodelling
- Kidney cancer research group
- Department of Laboratory Medicine
Publishing year
2020-03-17
Language
English
Publication/Series
Frontiers in cell and developmental biology
Volume
8
Document type
Journal article
Publisher
Frontiers Media S. A.
Topic
- Cancer and Oncology
Status
Published
Research group
- Cancer and matrix remodelling
- Kidney cancer research group
ISBN/ISSN/Other
- ISSN: 2296-634X