The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here:

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Håkan Axelson

Håkan Axelson

Research team manager

Håkan Axelson

The STRIPAK Complex Regulates Response to Chemotherapy Through p21 and p27


  • Carmen Rodriguez-Cupello
  • Monica Dam
  • Laura Serini
  • Shan Wang
  • David Lindgren
  • Emelie Englund
  • Pontus Kjellman
  • Håkan Axelson
  • Alberto García Mariscal
  • Chris Madsen

Summary, in English

The STRIPAK complex has been linked to a variety of biological processes taking place during embryogenesis and development, but its role in cancer has only just started to be defined. Here, we expand on previous work indicating a role for the scaffolding protein STRIP1 in cancer cell migration and metastasis. We show that cell cycle arrest and decreased proliferation are seen upon loss of STRIP1 in MDA-MB-231 cells due to the induction of cyclin dependent kinase inhibitors, including p21 and p27. We demonstrate that p21 and p27 induction is observed in a subpopulation of cells having low DNA damage response and that the p21high/γH2AXlow ratio within single cells can be rescued by depleting MST3&4 kinases. While the loss of STRIP1 decreases cell proliferation and tumor growth, cells treated with low dosage of chemotherapeutics in vitro paradoxically escape therapy-induced senescence and begin to proliferate after recovery. This corroborates with already known research on the dual role of p21 and indicates that STRIP1 also plays a contradictory role in breast cancer, suppressing tumor growth, but once treated with chemotherapeutics, allowing for possible recurrence and decreased patient survival.


  • LUCC: Lund University Cancer Centre
  • Division of Translational Cancer Research
  • Cancer and matrix remodelling
  • Kidney cancer research group
  • Department of Laboratory Medicine

Publishing year





Frontiers in cell and developmental biology



Document type

Journal article


Frontiers Media S. A.


  • Cancer and Oncology



Research group

  • Cancer and matrix remodelling
  • Kidney cancer research group


  • ISSN: 2296-634X