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Carl Borrebaeck

Carl Borrebaeck

Professor

Carl Borrebaeck

Identification of a serum biomarker signature associated with metastatic prostate cancer

Author

  • Venera Kuci Emruli
  • Leena Liljedahl
  • Ulrika Axelsson
  • Corinna Richter
  • Lisa Theorin
  • Anders Bjartell
  • Hans Lilja
  • Jenny Donovan
  • David Neal
  • Freddie C. Hamdy
  • Carl A.K. Borrebaeck

Summary, in English

Purpose: Improved early diagnosis and determination of aggressiveness of prostate cancer (PC) is important to select suitable treatment options and to decrease over-treatment. The conventional marker is total prostate specific antigen (PSA) levels in blood, but lacks specificity and ability to accurately discriminate indolent from aggressive disease. Experimental design: In this study, we sought to identify a serum biomarker signature associated with metastatic PC. We measured 157 analytes in 363 serum samples from healthy subjects, patients with non-metastatic PC and patients with metastatic PC, using a recombinant antibody microarray. Results: A signature consisting of 69 proteins differentiating metastatic PC patients from healthy controls was identified. Conclusions and clinical relevance: The clinical value of this biomarker signature requires validation in larger independent patient cohorts before providing a new prospect for detection of metastatic PC.

Department/s

  • LUCC: Lund University Cancer Centre
  • Department of Immunotechnology
  • Create Health
  • Urological cancer, Malmö
  • EpiHealth: Epidemiology for Health
  • Clinical Chemistry, Malmö

Publishing year

2021-05-01

Language

English

Publication/Series

Proteomics - Clinical Applications

Volume

15

Issue

2-3

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Cancer and Oncology

Keywords

  • affinity proteomics
  • antibody microarrays
  • biomarkers
  • cancer
  • prostate cancer

Status

Published

Research group

  • Urological cancer, Malmö
  • Clinical Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 1862-8346