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Carl B

Carl Borrebaeck


Carl B

A multicenter study investigating the molecular fingerprint of psychological resilience in breast cancer patients : Study protocol of the SCAN-B resilience study


  • Ulrika Axelsson
  • Lisa Rydén
  • Per Johnsson
  • Patrik Edén
  • Johanna Månsson
  • Ingalill Rahm Hallberg
  • Carl A.K. Borrebaeck

Summary, in English

Background: Individual patients differ in their psychological response when receiving a cancer diagnosis, in this case breast cancer. Given the same disease burden, some patients master the situation well, while others experience a great deal of stress, depression and lowered quality of life. Patients with high psychological resilience are likely to experience fewer stress reactions and better adapt to and manage the life threat and the demanding treatment that follows the diagnosis. If this phenomenon of mastering difficult situations is reflected also in biomolecular processes is not much studied, nor has its capacity for impacting the cancer prognosis been addressed. This project specifically aims, for the first time, to investigate how a breast cancer patient's psychological resilience is coupled to biomolecular parameters using advanced "omics" and, as a secondary aim, whether it relates to prognosis and quality of life one year after diagnosis. Method: The study population consists of newly diagnosed breast cancer patients enrolled in the Sweden Cancerome Analysis Network - Breast (SCAN-B) at four hospitals in Sweden. At the time of cancer diagnosis, the patient fills out the standardized method to measure psychological resilience, the "Connor-Davidson Resilience scale" (CD-RISC), the quality of life measure SF-36, as well as providing social and socioeconomic variables. In addition, one blood sample is collected. At the one-year follow-up, the patient will be subjected to the same assessments, and we also collect information regarding smoking, exercise habits, and BMI, as well as patients' trust in the treatment and their satisfaction with the care and treatment. Discussion: This explorative hypothesis-generating project will pave the way for larger validation studies, potentially leading to a standardized method of measuring psychological resilience as an important parameter in cancer care. Revealing the body-mind interaction, in terms of psychological resilience and quality of life, will herald the development of truly personalized psychosocial care and cancer intervention treatment strategies. Trial registration: This is a retrospectively registered trial at, ID: NCT03430492on February 6, 2018.


  • Department of Immunotechnology
  • Breast Cancer Surgery
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
  • Department of Psychology
  • Computational Biology and Biological Physics - Has been reorganised
  • Pufendorf Institute for Advanced Studies
  • Health-promoting Complex Interventions
  • Create Health

Publishing year





BMC Cancer





Document type

Journal article


BioMed Central (BMC)


  • Cancer and Oncology


  • Biomolecular parameters
  • Body and mind
  • Breast cancer
  • Epigenetics
  • Psychological resilience
  • Quality of life
  • SF36



Research group

  • Breast Cancer Surgery
  • Health-promoting Complex Interventions


  • ISSN: 1471-2407