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Attovial-based antibody nanoarrays.

Author:
  • Peter Ellmark
  • Sara Ghatnekar-Nilsson
  • André Meister
  • Harry Heinzelmann
  • Lars Montelius
  • Christer Wingren
  • Carl Borrebaeck
Publishing year: 2009
Language: English
Pages: 5406-5413
Publication/Series: Proteomics
Volume: 9
Issue: 24
Document type: Journal article
Publisher: John Wiley & Sons

Abstract english

Antibody array-based technology is a powerful emerging tool in proteomics, but to enable global proteome analysis, antibody array layouts with even higher density has to be developed. To this end, we have further developed the first generation of a nanoarray platform, based on attoliter sized vials, attovials, which we have characterized and used for the detection of complement factor C1q in human serum samples. Finally, we demonstrated proof-of-concept for individual functionalisation of the attovials with a recombinant antibody.

Keywords

  • Immunology in the medical area
  • Condensed Matter Physics

Other

Published
  • ISSN: 1615-9861
Carl B
Carl Borrebaeck
E-mail: carl [dot] borrebaeck [at] immun [dot] lth [dot] se

Professor

Department of Immunotechnology

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