Menu

Javascript is not activated in your browser. This website needs javascript activated to work properly.
You are here

CD27(-) CD4(+) memory T cells define a differentiated memory population at both the functional and transcriptional levels

Author:
  • Åsa Schiött
  • Malin Lindstedt
  • Bengt Johansson Lindbom
  • E Roggen
  • Carl Borrebaeck
Publishing year: 2004
Language: English
Pages: 363-370
Publication/Series: Immunology
Volume: 113
Issue: 3
Document type: Journal article
Publisher: Wiley-Blackwell

Abstract english

The memory T-cell population is a heterogeneous population, including both effector cells, which exert a direct secondary immune response, and resting or intermediate cells, which serve as a reservoir and exert a possible regulatory role. To further dissect the T-cell memory population residing in the CD4(+) CD45RO(+) T-cell pool, we studied the functional properties of memory populations identified by the CD27 marker. This marker clearly divides the memory population into two groups. One group consists of effector cells lacking CD27 and displaying a high antigen recall response. The other group consists of an intermediate memory population, displaying CD27. This latter group lacks an antigen recall response and requires costimulation for T-cell receptor triggering. To evaluate the function of the CD27(+) memory pool, we analysed the transcriptional profile, using high-density microarray technology. These gene data strongly support the different functional profiles of CD27(+) and CD27(-) memory populations, in terms of protein expression and the capacity to respond to antigen.

Keywords

  • Immunology in the medical area

Other

Published
  • Adaptive Immunity
  • ISSN: 0019-2805
Carl B
Carl Borrebaeck
E-mail: carl [dot] borrebaeck [at] immun [dot] lth [dot] se

Professor

Department of Immunotechnology

313k1

90

Director

Create Health

+46 46 222 96 13

313k1

90