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Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma

Author:
  • Josefin Fernebro
  • Princy Francis
  • Patrik Edén
  • Åke Borg
  • Ioannis Panagopoulos
  • Fredrik Mertens
  • Johan Vallon-Christersson
  • Måns Åkerman
  • Anders Rydholm
  • H Bauer
  • Nils Mandahl
  • Mef Nilbert
Publishing year: 2006
Language: English
Pages: 1165-1172
Publication/Series: International Journal of Cancer
Volume: 118
Issue: 5
Document type: Journal article
Publisher: John Wiley & Sons

Abstract english

We applied 27k spotted cDNA microarray slides to assess gene expression profiles in 26 samples from 24 patients with synovial sarcomas (SS). The data were analyzed in relation to histopathologic type, cytogenetic aberrations, gene fusion type and development of distant metastases. Supervised analysis based on gene fusion type in 12 SS with SS18/SSXI and 9 with SS18/SSX2 revealed significant differences in gene expression profiles. Among the discriminators were several genes that have previously been found to be upregulated in SS, including AXL, ZIC2, SPAG7, AGRN, FOXC1, NCAM1 and multiple metallothioneins. Histopathology and degree of cytogenetic complexity did not significantly influence expression, whereas a genetic signature that related to development of metastases could be discerned, albeit with a high false-positive rate. In conclusion, our findings demonstrate differentially expressed genes for the 2 major gene fusion variants in SS, SS18/SSX1 and SS18/SSX2, and thereby suggest that these result in different downstream effects. (c) 2005 Wiley-Liss, Inc.

Keywords

  • Cancer and Oncology
  • gene expression
  • synovial sarcoma
  • cDNA microarray
  • SS18/SSX

Other

Published
  • ISSN: 0020-7136
Åke Borg
Åke Borg
E-mail: ake [dot] borg [at] med [dot] lu [dot] se

Principal investigator

Oncology and Pathology, MV

+46 46 275 25 52

MV 404 C21B2

90

Project manager

Familial Breast Cancer

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Professor

Oncology and Pathology, MV

MV 404 C21C2

90