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Åke Borg

Åke Borg

Principal investigator

Åke Borg

Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns

Author

  • Sofia Gruvberger
  • Markus Ringnér
  • Yidong Chen
  • Sujatha Panavally
  • Lao Saal
  • Mårten Fernö
  • Carsten Peterson
  • Paul S. Meltzer
  • Åke Borg

Summary, in English

To investigate the phenotype associated with estrogen receptor alpha (ER) expression in breast carcinoma, gene expression profiles of 58 node-negative breast carcinomas discordant for ER status were determined using DNA microarray technology. Using artificial neural networks as well as standard hierarchical clustering techniques, the tumors could be classified according to ER status, and a list of genes which discriminate tumors according to ER status was generated. The artificial neural networks could accurately predict ER status even when excluding top discriminator genes, including ER itself. By reference to the serial analysis of gene expression database, we found that only a small proportion of the 100 most important ER discriminator genes were also regulated by estradiol in MCF-7 cells. The results provide evidence that ER+ and ER- tumors display remarkably different gene-expression phenotypes not solely explained by differences in estrogen responsiveness.

Department/s

  • Breastcancer-genetics
  • Computational Biology and Biological Physics - Undergoing reorganization

Publishing year

2001-08-15

Language

English

Pages

5979-5984

Publication/Series

Cancer Research

Volume

61

Issue

16

Document type

Journal article

Publisher

American Association for Cancer Research Inc.

Topic

  • Cancer and Oncology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1538-7445