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Åke Borg

Åke Borg

Principal investigator

Åke Borg

Butler enables rapid cloud-based analysis of thousands of human genomes

Author

  • Sergei Yakneen
  • Sebastian M Waszak
  • Michael Gertz
  • Jan O Korbel

Other contributions

  • Åke Borg
  • Markus Ringnér
  • Johan Staaf

Summary, in English

We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.

Department/s

  • LUCC: Lund University Cancer Centre
  • Familial Breast Cancer
  • Breastcancer-genetics
  • Molecular Cell Biology
  • Breast/lungcancer
  • Division of Translational Cancer Research
  • Research Group Lung Cancer

Publishing year

2020-03

Language

English

Pages

288-292

Publication/Series

Nature Biotechnology

Volume

38

Issue

3

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Bioinformatics (Computational Biology)

Keywords

  • Cloud Computing
  • Computational Biology/methods
  • Genome, Human
  • Humans
  • Neoplasms/genetics
  • Software

Status

Published

Research group

  • Familial Breast Cancer
  • Research Group Lung Cancer

ISBN/ISSN/Other

  • ISSN: 1546-1696