Åke Borg
Principal investigator
Serum copper, zinc and copper/zinc ratio in relation to survival after breast cancer diagnosis: A prospective multicenter cohort study
Author
Summary, in English
Background
The essential trace elements copper and zinc, and their ratio (copper/zinc), are important for maintaining redox homeostasis. Previous studies suggest that these elements may impact breast cancer survival. However, no epidemiological study has so far been conducted on the potential association between copper and copper/zinc levels and survival after breast cancer diagnosis. In this study, we aimed to examine the relationship between serum copper, zinc and copper/zinc levels and survival following breast cancer diagnosis.
Patients and methods
The Sweden Cancerome Analysis Network – Breast Initiative (SCAN-B) is a population-based cohort study including multiple participating hospitals in Sweden. A total of 1998 patients diagnosed with primary invasive breast cancer were followed for approximately nine years. Serum levels of copper and zinc and their ratio at the time of diagnosis was analyzed in relation to breast cancer survival using multivariate Cox regression, yielding hazard ratios (HR) with 95% confidence intervals.
Results
A higher copper/zinc ratio was associated with lower overall survival after breast cancer diagnosis. Comparing patients with a copper/zinc ratio in quartile 4 vs 1, the crude HR was 2.29 (1.65–3.19) (Ptrend
Conclusion
There is evidence that the serum copper/zinc ratio provides an independent predictive value for overall survival following breast cancer diagnosis.
The essential trace elements copper and zinc, and their ratio (copper/zinc), are important for maintaining redox homeostasis. Previous studies suggest that these elements may impact breast cancer survival. However, no epidemiological study has so far been conducted on the potential association between copper and copper/zinc levels and survival after breast cancer diagnosis. In this study, we aimed to examine the relationship between serum copper, zinc and copper/zinc levels and survival following breast cancer diagnosis.
Patients and methods
The Sweden Cancerome Analysis Network – Breast Initiative (SCAN-B) is a population-based cohort study including multiple participating hospitals in Sweden. A total of 1998 patients diagnosed with primary invasive breast cancer were followed for approximately nine years. Serum levels of copper and zinc and their ratio at the time of diagnosis was analyzed in relation to breast cancer survival using multivariate Cox regression, yielding hazard ratios (HR) with 95% confidence intervals.
Results
A higher copper/zinc ratio was associated with lower overall survival after breast cancer diagnosis. Comparing patients with a copper/zinc ratio in quartile 4 vs 1, the crude HR was 2.29 (1.65–3.19) (Ptrend
Conclusion
There is evidence that the serum copper/zinc ratio provides an independent predictive value for overall survival following breast cancer diagnosis.
Department/s
- LUCC: Lund University Cancer Centre
- Surgery
- Breastcancer-genetics
- Translational Oncogenomics
- The Liquid Biopsy and Tumor Progression in Breast Cancer
- Breast Cancer Surgery
- Familial Breast Cancer
- EpiHealth: Epidemiology for Health
Publishing year
2023-05-16
Language
English
Publication/Series
Redox Biology
Volume
63
Document type
Journal article
Publisher
Elsevier
Topic
- Cancer and Oncology
Status
Published
Project
- Sweden Cancerome Analysis Network - Breast (SCAN-B): a large-scale multicenter infrastructure towards implementation of breast cancer genomic analyses in the clinical routine
- Trace Elements and Breast Cancer: Selenium, Zinc and Copper in Relation to Risk and Prognosis
Research group
- Surgery
- Translational Oncogenomics
- The Liquid Biopsy and Tumor Progression in Breast Cancer
- Breast Cancer Surgery
- Familial Breast Cancer
ISBN/ISSN/Other
- ISSN: 2213-2317