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Åke Borg

Åke Borg

Principal investigator

Åke Borg

Correlation between estradiol-17 beta and progesterone cytosol receptor concentration, histologic differentiation and 3H-thymidine incorporation in endometrial carcinoma

Author

  • B Lindahl
  • P Alm
  • A Borg
  • M Fernö
  • H Grundsell
  • J E Johnsson
  • A Norgren
  • Claes Trope

Summary, in English

Women treated with estrogen exhibit a higher risk of developing endometrial cancer. steroid hormones exert their effects on target tissue through specific cytosol receptor protein. Knowledge of this steroid receptor concentration in endometrial carcinoma might facilitate the treatment of recurrences. We have compared the concentrations of endometrial estrogen and progesterone cytosol receptors with the histologic grade of endometrial carcinoma as well as the rate of 3H-thymidine incorporation. We found a significant difference in receptor concentration between well-moderately differentiated tumours and poorly differentiated ones. No correlation was found between 3H-thymidine incorporation rate and differentiation. A positive correlation between thymidine incorporation rate and progesterone receptor concentration was noticed. The concentration of receptors varies within a wide range of each group of differentiation; thus 23% and 4% of the poorly differentiated tumours had higher concentration of estradiol and progesterone receptors respectively than the median values for well differentiated tumours.

Department/s

  • Obstetrics and Gynaecology (Lund)
  • Tumor microenvironment
  • Breastcancer-genetics
  • Familial Breast Cancer
  • Personalized Breast Cancer Treatment

Publishing year

1982-07-01

Language

English

Pages

7-203

Publication/Series

Anticancer research

Volume

2

Issue

4

Document type

Journal article

Publisher

International Institute of Cancer Research

Topic

  • Cancer and Oncology

Keywords

  • Cytosol/analysis
  • Female
  • Humans
  • Receptors, Estradiol
  • Receptors, Estrogen/analysis
  • Receptors, Progesterone/analysis
  • Thymidine/metabolism
  • Tritium
  • Uterine Neoplasms/analysis

Status

Published

Research group

  • Familial Breast Cancer
  • Personalized Breast Cancer Treatment

ISBN/ISSN/Other

  • ISSN: 0250-7005