Permanent alterations induced in plasma prolactin and estrogen receptor concentration in benign and malignant tissue of women who started oral contraceptive use at an early age

Summary, in English

In 65 young women undergoing curettage for benign utrine disorders a signicicant relationship was found between early oral contraceptive use (starting age<25 years) and a high ratio of ln plasma prolactin versus ln estrogen receptor concentration of the uterine mucosae (p<0.047, Mann-Whitneys U-test). Year of birth, age at menarche, age at first full term pregnancy, parity, menstrual cycle phase and duration of oral contraceptive use could not explain the results. Because similar results have previously been found for breast cancer patients using plasma prolactin and breast tumour estrogen receptor concentration, the findings indicate that early oral contraceptive use permanently alters plasma prolactin levels and estrogen receptor concentration, both in benign uterine tissue and in malignant breast tumours.

• Author: H. Olsson; B. Lindahl; J. Ranstam; A. Borg; M. Ferno; A. Norgren
• Department/s: Tumor microenvironment; Obstetrics and Gynaecology (Lund); Breastcancer-genetics
• Publishing year: 1987-01-01
• Language: English
• Pages: 853-856
• Publication/Series: Anticancer research
• Volume: 7
• Issue: 4 B
• Document type: Journal article
• Publisher: International Institute of Cancer Research
• Topic: Cancer and Oncology
• Status: Published
• ISBN/ISSN/Other: ISSN: 0250-7005