Åke Borg
Principal investigator
Flow cytometric DNA index and S-phase fraction in breast cancer in relation to other prognostic variables and to clinical outcome
Author
Summary, in English
One frequently used classification of flow cytometric DNA ploidy status (diploid versus nondiploid) was compared with a division into seven ploidy classes based on DNA index (DI) and number of cell populations (hypodiploid, diploid, near-hyperdiploid, hyperdiploid, tetraploid, hypertetraploid, and multiploid). The latter ploidy classification showed a better correlation with prognosis and other prognostic factors (i.e., lymph node involvement, estrogen and progesterone receptor status, and S-phase fraction). The improvement in correlation was mainly due to the identification of near-hyperdiploid cases (DI 1.00-1.14) which could be combined with the diploid cases to form a group with favourable prognosis. In contrast to cases with a small increase in DNA content (near-hyperdiploid), those with a small decrease of DNA content (hypodiploid) manifested a more aggressive disease. In multivariate analysis, S-phase fraction (SPF) was a more important prognostic factor than both the improved or the conventional ploidy classification.
Department/s
- Breastcancer-genetics
Publishing year
1992
Language
English
Pages
157-165
Publication/Series
Acta Oncologica
Volume
31
Issue
2
Document type
Journal article
Publisher
Taylor & Francis
Topic
- Cancer and Oncology
Keywords
- Breast cancer
- flow cytometry
- DNA-index
- ploidy
- S-phase
- interphase
- proliferation
- prognosis
Status
Published
ISBN/ISSN/Other
- ISSN: 1651-226X