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Flow cytometric DNA index and S-phase fraction in breast cancer in relation to other prognostic variables and to clinical outcome

Author:
  • Mårten Fernö
  • Bo Baldetorp
  • Åke Borg
  • Håkan Olsson
  • Helgi Sigurdsson
  • Dick Killander
Publishing year: 1992
Language: English
Pages: 157-165
Publication/Series: Acta Oncologica
Volume: 31
Issue: 2
Document type: Journal article
Publisher: Taylor & Francis

Abstract english

One frequently used classification of flow cytometric DNA ploidy status (diploid versus nondiploid) was compared with a division into seven ploidy classes based on DNA index (DI) and number of cell populations (hypodiploid, diploid, near-hyperdiploid, hyperdiploid, tetraploid, hypertetraploid, and multiploid). The latter ploidy classification showed a better correlation with prognosis and other prognostic factors (i.e., lymph node involvement, estrogen and progesterone receptor status, and S-phase fraction). The improvement in correlation was mainly due to the identification of near-hyperdiploid cases (DI 1.00-1.14) which could be combined with the diploid cases to form a group with favourable prognosis. In contrast to cases with a small increase in DNA content (near-hyperdiploid), those with a small decrease of DNA content (hypodiploid) manifested a more aggressive disease. In multivariate analysis, S-phase fraction (SPF) was a more important prognostic factor than both the improved or the conventional ploidy classification.

Keywords

  • Cancer and Oncology
  • Breast cancer
  • flow cytometry
  • DNA-index
  • ploidy
  • S-phase
  • interphase
  • proliferation
  • prognosis

Other

Published
  • ISSN: 1651-226X
Åke Borg
Åke Borg
E-mail: ake [dot] borg [at] med [dot] lu [dot] se

Principal investigator

Oncology and Pathology, MV

+46 46 275 25 52

MV 404 C21B2

90

Project manager

Familial Breast Cancer

90

Professor

Oncology and Pathology, MV

MV 404 C21C2

90