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Åke Borg

Åke Borg

Principal investigator

Åke Borg

HER-2/neu amplification predicts poor survival in node-positive breast cancer

Author

  • A Borg
  • A K Tandon
  • H Sigurdsson
  • G M Clark
  • M Fernö
  • S A Fuqua
  • D Killander
  • W L McGuire

Summary, in English

HER-2/neu protooncogene amplification and protein expression were analyzed with slot blot and Western blot techniques, respectively, in more than 300 invasive primary breast tumors of all stages. Amplification (2- greater than 30 copies) was found in 17% of these tumors and high expression was seen in 19%. There was a striking coincidence between gene amplification and high expression. Tumors associated with many involved axillary lymph nodes or with Stage IV disease were more often HER-2/neu amplified or overexpressed. Furthermore, gene alteration was strongly correlated with the absence of steroid receptors and with larger tumor size. High expression without gene amplification was seen in a minor subset of tumors of less aggressive character. Neither amplification nor overexpression was correlated with disease outcome for patients with negative axillary lymph nodes. For node-positive patients, however, HER-2/neu amplification was a significant predictor of early relapse and death (median follow-up = 45 months), and a similar trend, although not significant, existed for high gene expression. Multivariate analyses indicated that HER-2/neu alterations were not independent predictors of patient outcome.

Department/s

  • Breastcancer-genetics
  • Personalized Breast Cancer Treatment
  • Tumor microenvironment

Publishing year

1990-07-15

Language

English

Pages

7-4332

Publication/Series

Cancer Research

Volume

50

Issue

14

Document type

Journal article

Publisher

American Association for Cancer Research Inc.

Topic

  • Cancer and Oncology

Keywords

  • Amino Acid Sequence
  • Biomarkers, Tumor/analysis
  • Blotting, Western
  • Breast Neoplasms/analysis
  • Female
  • Gene Amplification
  • Gene Expression
  • Humans
  • Immune Sera
  • Lymphatic Metastasis
  • Menopause
  • Molecular Sequence Data
  • Peptides/chemical synthesis
  • Prognosis
  • Protein-Tyrosine Kinases/genetics
  • Proto-Oncogene Proteins/analysis
  • Proto-Oncogenes
  • Receptor, ErbB-2
  • Receptors, Estrogen/analysis
  • Receptors, Progesterone

Status

Published

Research group

  • Personalized Breast Cancer Treatment

ISBN/ISSN/Other

  • ISSN: 0008-5472