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Thoas Fioretos

Thoas Fioretos

Research team manager

Thoas Fioretos

A novel SERPINE1-FOSB fusion gene results in transcriptional up-regulation of FOSB in pseudomyogenic haemangioendothelioma.

Author

  • Charles Walther
  • Johnbosco Tayebwa
  • Henrik Lilljebjörn
  • Linda Magnusson
  • Jenny Nilsson
  • Fredrik Vult von Steyern
  • Ingrid Øra
  • Henryk Domanski
  • Thoas Fioretos
  • Karolin Hansén Nord
  • Christopher Dm Fletcher
  • Fredrik Mertens
Show all

Summary, in English

Pseudomyogenic haemangioendothelioma (PHE) is an intermediate malignant vascular soft tissue tumour primarily affecting children and young adults. The molecular basis of this neoplasm is unknown. We here used chromosome banding analysis, fluorescence in situ hybridization (FISH), mRNA sequencing, RT-PCR and quantitative real-time PCR on a series of morphologically well-characterized PHEs to show that a balanced translocation, t(7;19)(q22;q13), detected as the sole cytogenetic aberration in two cases, results in fusion of the SERPINE1 and FOSB genes. This translocation has not been observed in any other bone or soft tissue tumour. Interphase FISH on sections from eight additional PHEs identified the same SERPINE1-FOSB fusion in all cases. The role of SERPINE1, which is highly expressed in vascular cells, in this gene fusion is probably to provide a strong promoter for FOSB, which was found to be expressed at higher levels in PHEs than in other soft tissue tumours. FOSB encodes a transcription factor belonging to the FOS family of proteins, which, together with members of the JUN family of transcription factors, are major components of the activating protein 1 (AP-1) complex. Further studies are needed to understand the cellular impact of the aberrant expression of the FOSB gene, but as the t(7;19) resulting in the SERPINE1-FOSB fusion seems to be pathognomonic for PHE, FISH or RT-PCR could be useful for differential diagnostic purposes. Published by John Wiley & Sons, Ltd. www.pathsoc.org.uk.

Department/s

  • The genetics of soft tissue tumors
  • Division of Clinical Genetics
  • Orthopaedics (Lund)
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
  • Paediatrics (Lund)
  • Tumor microenvironment

Publishing year

2014

Language

English

Pages

534-540

Publication/Series

Journal of Pathology

Volume

232

Issue

5

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Medical Genetics
  • Cancer and Oncology

Status

Published

Research group

  • The genetics of soft tissue tumors

ISBN/ISSN/Other

  • ISSN: 0022-3417