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Thoas Fioretos

Thoas Fioretos

Research team manager

Thoas Fioretos

No evidence for genomic imprinting of the human BCR gene

Author

  • Thoas Fioretos
  • Nora Heisterkamp
  • John Groffen

Summary, in English

Chronic myeloid leukemias and 5% to 20% of acute lymphoid leukemias are characterized by the Philadelphia chromosome, a reciprocal chromosomal translocation, t(9;22)(q34;q11), generating BCR-ABL and ABL-BCR fusion genes. Cytogenetic studies have recently shown a preferential involvement of the paternally derived chromosome 9 and the maternally derived chromosome 22 in this translocation, indicating that imprinting might be involved in the formation or selection of the translocation. In this study, we have identified a BamHI polymorphism in the coding region of BCR exon 1, allowing us to investigate whether both BCR alleles are transcribed. By using a reverse transcriptase-polymerase chain reaction assay, we show that both BCR alleles are expressed in the peripheral blood cells of normal individuals.

Department/s

  • Division of Clinical Genetics

Publishing year

1994

Language

English

Pages

3441-3444

Publication/Series

Blood

Volume

83

Issue

12

Document type

Journal article

Publisher

American Society of Hematology

Topic

  • Hematology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1528-0020