The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Thoas Fioretos

Thoas Fioretos

Research team manager

Thoas Fioretos

Molecular analysis of Philadelphia-positive childhood chronic myeloid leukemia.

Author

  • Thoas Fioretos
  • Sverre Heim
  • Stanislaw Garwicz
  • J Ludvigsson
  • Felix Mitelman

Summary, in English

The breakpoints in chromosome 22 were determined in five children with Philadelphia-positive chronic myeloid leukemia. All had rearrangements within the major breakpoint cluster region (M-bcr). Four patients had breakpoints in the 5' region of M-bcr (zones 1-3), whereas one had a rearrangement in the 3' region (zone 4). The patient with the 3' rearrangement was the only one to develop a lymphoid blast crisis; he also had a substantially longer survival (102 months) than the others (11-54 months).

Department/s

  • Division of Clinical Genetics
  • Paediatrics (Lund)

Publishing year

1992

Language

English

Pages

723-725

Publication/Series

Leukemia

Volume

6

Issue

7

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Cancer and Oncology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1476-5551