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Thoas Fioretos

Thoas Fioretos

Research team manager

Thoas Fioretos

Loss of the tumor suppressor gene AIP mediates the browning of human brown fat tumors

Author

  • Linda Magnusson
  • Nils Hansen
  • Karim H Saba
  • Jenny Nilsson
  • Thoas Fioretos
  • Pehr Rissler
  • Karolin Hansén Nord

Summary, in English

Human brown fat tumors (hibernomas) display concomitant loss of the tumor suppressor genes MEN1 and AIP. In the present study, we hypothesized that the brown fat phenotype is attributed to these mutations. Accordingly, we demonstrate that silencing of AIP in human brown preadipocytic and white fat cell lines results in the induction of the brown fat marker UCP1. In human adipocytic tumors, loss of MEN1 was found both in white (one out of 51 lipomas) and brown fat tumors. In contrast, concurrent loss of AIP was always accompanied by a brown fat morphology. We conclude that this white-to-brown phenotype switch in brown fat tumors is mediated by the loss of AIP.

Department/s

  • Division of Clinical Genetics
  • Genetic chaos in aggressive cancer
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
  • Tumor microenvironment

Publishing year

2017-10

Language

English

Pages

160-164

Publication/Series

Journal of Pathology

Volume

243

Issue

2

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Medical Genetics
  • Cancer and Oncology

Keywords

  • Journal Article

Status

Published

Research group

  • Genetic chaos in aggressive cancer

ISBN/ISSN/Other

  • ISSN: 0022-3417