Thoas Fioretos
Research team manager
Loss of the tumor suppressor gene AIP mediates the browning of human brown fat tumors
Author
Summary, in English
Human brown fat tumors (hibernomas) display concomitant loss of the tumor suppressor genes MEN1 and AIP. In the present study, we hypothesized that the brown fat phenotype is attributed to these mutations. Accordingly, we demonstrate that silencing of AIP in human brown preadipocytic and white fat cell lines results in the induction of the brown fat marker UCP1. In human adipocytic tumors, loss of MEN1 was found both in white (one out of 51 lipomas) and brown fat tumors. In contrast, concurrent loss of AIP was always accompanied by a brown fat morphology. We conclude that this white-to-brown phenotype switch in brown fat tumors is mediated by the loss of AIP.
Department/s
- Division of Clinical Genetics
- Genetic chaos in aggressive cancer
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- Tumor microenvironment
Publishing year
2017-10
Language
English
Pages
160-164
Publication/Series
Journal of Pathology
Volume
243
Issue
2
Document type
Journal article
Publisher
John Wiley & Sons Inc.
Topic
- Medical Genetics
- Cancer and Oncology
Keywords
- Journal Article
Status
Published
Research group
- Genetic chaos in aggressive cancer
ISBN/ISSN/Other
- ISSN: 0022-3417