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Loss of the tumor suppressor gene AIP mediates the browning of human brown fat tumors

Author:
  • Linda Magnusson
  • Nils Hansen
  • Karim H Saba
  • Jenny Nilsson
  • Thoas Fioretos
  • Pehr Rissler
  • Karolin Hansén Nord
Publishing year: 2017-10
Language: English
Pages: 160-164
Publication/Series: Journal of Pathology
Volume: 243
Issue: 2
Document type: Journal article
Publisher: John Wiley & Sons

Abstract english

Human brown fat tumors (hibernomas) display concomitant loss of the tumor suppressor genes MEN1 and AIP. In the present study, we hypothesized that the brown fat phenotype is attributed to these mutations. Accordingly, we demonstrate that silencing of AIP in human brown preadipocytic and white fat cell lines results in the induction of the brown fat marker UCP1. In human adipocytic tumors, loss of MEN1 was found both in white (one out of 51 lipomas) and brown fat tumors. In contrast, concurrent loss of AIP was always accompanied by a brown fat morphology. We conclude that this white-to-brown phenotype switch in brown fat tumors is mediated by the loss of AIP.

Keywords

  • Medical Genetics
  • Cancer and Oncology
  • Journal Article

Other

Published
  • Genetic chaos in aggressive cancer
  • ISSN: 0022-3417
Thoas Fioretos
E-mail: thoas [dot] fioretos [at] med [dot] lu [dot] se

Principal investigator

Translational Genomic and Functional Studies of Leucemia

+46 46 222 45 95

+46 70 334 33 67

BMC C13

66

Professor

Division of Clinical Genetics

+46 46 222 45 95

+46 70 334 33 67

BMC C13

66

Professor

Translational Genomic and Functional Studies of Leucemia

+46 46 222 45 95

+46 70 334 33 67

BMC C13

66