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Thoas Fioretos

Thoas Fioretos

Research team manager

Thoas Fioretos

Remarkably long survival of a patient with Ph1-positive chronic myeloid leukemia and 5' bcr rearrangement

Author

  • Bertil Johansson
  • Fredrik Mertens
  • Thoas Fioretos
  • Sverre Heim
  • Ulf Kristoffersson
  • Nils Mandahl
  • C R Bartram
  • Felix Mitelman

Summary, in English

Chronic myeloid leukemia (CML) was diagnosed in a 19-year-old man in 1961, and the disease remained in chronic phase, with occasional exacerbations, for 27 years. In 1976, when the first cytogenetic analysis was performed, t(9;22)(q34;q11) was found as the sole abnormality in all mitoses. During accelerated phase in 1988, a second cytogenetic investigation showed the karyotype 45,XY,t(9;22)(q34;q11),-15,-17,+der(15) t(15;17)(p13;q11). Molecular analysis revealed a rearrangement in the 5' end of the major breakpoint cluster region (M-bcr). With the case presented here, sublocalization of the bcr breakpoint has now been undertaken in altogether five CML patients with extremely long survival. It is noteworthy that in all these cases the chromosome 22 breakpoint was located in the 5' region of the M-bcr.

Department/s

  • Division of Clinical Genetics

Publishing year

1990

Language

English

Pages

448-449

Publication/Series

Leukemia

Volume

4

Issue

6

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Cancer and Oncology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1476-5551