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Thoas Fioretos

Thoas Fioretos

Research team manager

Thoas Fioretos

Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A.

Author

  • Kristina Karrman
  • Anders Castor
  • Mikael Behrendtz
  • Erik Forestier
  • Linda Olsson
  • Mats Ehinger
  • Andrea Biloglav
  • Thoas Fioretos
  • Kajsa Paulsson
  • Bertil Johansson

Summary, in English

Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations, subsequently giving rise to a malignant, clonal expansion of T-lymphoblasts. The aim of the present study was to identify additional as well as cooperative genetic events in T-ALL.

Department/s

  • Genetic and epigenetic studies of pediatric leukemia
  • Division of Clinical Genetics
  • Paediatrics (Lund)
  • Tumor microenvironment
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation

Publishing year

2015

Language

English

Publication/Series

Journal of Hematology & Oncology

Volume

8

Issue

1

Document type

Journal article

Publisher

BioMed Central (BMC)

Topic

  • Medical Genetics
  • Pediatrics
  • Cancer and Oncology

Status

Published

Research group

  • Genetic and epigenetic studies of pediatric leukemia

ISBN/ISSN/Other

  • ISSN: 1756-8722