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Thoas Fioretos

Thoas Fioretos

Research team manager

Thoas Fioretos

SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function.

Author

  • Nils Hansen
  • Helena Ågerstam
  • Martin Wahlestedt
  • Niklas Landberg
  • Maria Askmyr
  • Mats Ehinger
  • Marianne Rissler
  • Henrik Lilljebjörn
  • Petra Johnels
  • J Ishiko
  • J V Melo
  • Alexander Whalen
  • David Bryder
  • Marcus Järås
  • Thoas Fioretos
Show all

Summary, in English

Suppressor of cytokine signaling 2 (SOCS2) is known as a feedback inhibitor of cytokine signaling and is highly expressed in primary bone marrow (BM) cells from patients with chronic myeloid leukemia (CML). However, it has not been established whether SOCS2 is involved in CML, caused by the BCR/ABL1 fusion gene, or important for normal hematopoietic stem cell (HSC) function. In this study, we demonstrate that although Socs2 was found to be preferentially expressed in long-term HSCs, Socs2-deficient HSCs were indistinguishable from wild-type HSCs when challenged in competitive BM transplantation experiments. Furthermore, by using a retroviral BCR/ABL1-induced mouse model of CML, we demonstrate that SOCS2 is dispensable for the induction and propagation of the disease, suggesting that the SOCS2-mediated feedback regulation of the JAK/STAT pathway is deficient in BCR/ABL1-induced CML.Leukemia advance online publication, 24 July 2012; doi:10.1038/leu.2012.169.

Department/s

  • Division of Clinical Genetics
  • Department of Experimental Medical Science
  • Tumor microenvironment
  • Family Medicine and Clinical Epidemiology
  • StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation

Publishing year

2013

Language

English

Pages

130-135

Publication/Series

Leukemia

Volume

27

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Cancer and Oncology

Status

Published

Research group

  • Family Medicine and Clinical Epidemiology

ISBN/ISSN/Other

  • ISSN: 1476-5551