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From critters to cancers: bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia

  • D. Hoogewijs
  • N. B. Terwilliger
  • K. A. Webster
  • J. A. Powell-Coffman
  • S. Tokishita
  • H. Yamagata
  • T. Hankeln
  • T. Burmester
  • K. T. Rytkonen
  • M. Nikinmaa
  • D. Abele
  • K. Heise
  • M. Lucassen
  • J. Fandrey
  • R. H. Maxwell
  • Sven Påhlman
  • T. A. Gorr
Publishing year: 2007
Language: English
Pages: 552-577
Publication/Series: Integrative and Comparative Biology
Volume: 47
Issue: 4
Document type: Journal article
Publisher: Oxford University Press

Abstract english

The objective of this symposium at the First International Congress of Respiratory Biology (ICRB) was to enhance communication between comparative biologists and cancer researchers working on O-2 sensing via the HIF pathway. Representatives from both camps came together on August 13-16, 2006, in Bonn, Germany, to discuss molecular adaptations that occur after cells have been challenged by a reduced (hypoxia) or completely absent (anoxia) supply of oxygen. This brief "critters-to-cancer" survey discusses current projects and new directions aimed at improving understanding of hypoxic signaling and developing therapeutic interventions.


  • Cancer and Oncology


  • ISSN: 1557-7023
Sven Påhlman
E-mail: sven [dot] pahlman [at] med [dot] lu [dot] se


Division of Translational Cancer Research

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