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Hypoxia inducible factor-2alpha in cancer.

  • Tobias Löfstedt
  • Erik Fredlund
  • Linda Holmquist Mengelbier
  • Alexander Pietras
  • Marie Ovenberger
  • Lorenz Poellinger
  • Sven Påhlman
Publishing year: 2007
Language: English
Pages: 919-926
Publication/Series: Cell Cycle
Volume: 6
Issue: 8
Document type: Journal article
Publisher: Landes Bioscience

Abstract english

Poorly oxygenated ( hypoxic) tumors are frequently more aggressive compared to corresponding tumors that are better oxygenated. Adaptation to hypoxia is primarily mediated by two closely related hypoxia inducible transcription factor complexes, HIF-1 and HIF-2, which become stabilized and activated at low oxygen levels. Whether HIF-1 and HIF-2 have different roles in tumorigenesis is an open question and an issue we discuss. With focus on HIF-2, we summarize reported phenotypical changes of HIF genetic models and HIF expression patterns during normal development, in adult non - malignant tissues and in tumors. We further address the much - discussed subject of target gene preferences between HIF-1 and HIF-2, given that both transcription factors bind to the same DNA motif. Finally, we also discuss the observations that the oxygen - sensitive HIF-2 alpha subunit is accumulated and active under non - hypoxic conditions as exemplified by HIF-2 alpha expressing tumor macrophages and neuroblastoma cells located in seemingly well - vascularized tumor regions and how this phenomenon is related to tumor aggressiveness.


  • Cell Biology
  • target genes
  • neuroblastoma
  • regulation
  • development
  • adaptation
  • hypoxia
  • cancer
  • hypoxia-inducible factor


  • ISSN: 1551-4005
Sven Påhlman
E-mail: sven [dot] pahlman [at] med [dot] lu [dot] se


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