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Reduced postnatal cerebral glucose metabolism measured by PET after asphyxia in near term fetal lambs

Author:
  • Kristina Thorngren-Jerneck
  • David Ley
  • Lena Hellström-Westas
  • Edgar Hernandez-Andrade
  • Göran Lingman
  • Tomas G Ohlsson
  • Gylfi Oskarsson
  • Erkki Pesonen
  • Anders Sandell
  • Sven-Erik Strand
  • Olof Werner
  • Karel Marsal
Publishing year: 2001
Language: English
Pages: 844-850
Publication/Series: Journal of Neuroscience Research
Volume: 66
Issue: 5
Document type: Journal article
Publisher: John Wiley & Sons

Abstract english

The effects of fetal asphyxia on cerebral function and development, involve the transition from fetal to neonatal life. Changes in cerebral glucose metabolism may be an early postnatal indicator of fetal asphyxia. The objective is to develop an experimental lamb model involving the transition from fetal to neonatal life and to examine the effect of fetal asphyxia with cerebral hypoxic ischemia on early postnatal cerebral glucose metabolism. Fetal asphyxia was induced by total umbilical cord occlusion in eight near-term fetal lambs (134-138 days) with the ewe under isoflurane-opiate anesthesia. The mean occlusion time until cardiac arrest was 14.5 (4.2) min (SD). Lambs were immediately delivered and standardized resuscitation was instituted after 2 min asystole. At 4 hr postnatal age, [18-F]Fluoro-2-deoxy-glucose (18-FDG) was injected intravenously in eight asphyxiated lambs and in eight controls. Cerebral glucose metabolism was examined by positron emission tomography (PET). As a result the mean arterial blood pressure, acid-base values, blood glucose and serum lactate at 4 hr postnatal age did not differ significantly between lambs subjected to umbilical cord occlusion and controls. EEG was abnormal in all lambs subjected to cord occlusion and normal in the controls at 4 hr postnatal age. Global cerebral metabolic rate (CMRgl) as determined by PET was significantly lower in lambs subjected to cord occlusion mean/median (SD) 22.2/19.6 (8.4) micromol/min/100 g) than in controls mean/median (SD) 37.8/35.9 (6.1); P < 0.01). Global CMRgl is significantly reduced in newborn lambs 4 hr after fetal asphyxia induced by umbilical cord occlusion. A reduction in CMRgl is an early indicator of global hypoxic cerebral ischemia.

Keywords

  • Neurosciences
  • fetal lamb
  • asphyxia
  • cerebral glucose metabolism
  • positron emission tomography

Other

Published
  • ISSN: 1097-4547
Sven-Erik Strand
E-mail: sven-erik [dot] strand [at] med [dot] lu [dot] se

Project manager

Systemic Radiation Therapy Group

32

Professor emeritus

Medical Radiation Physics, Lund

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