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A 3-dimensional absorbed dose calculation method based on quantitative SPECT for radionuclide therapy: evaluation for (131)I using monte carlo simulation.

  • Michael Ljungberg
  • Katarina Sjögreen Gleisner
  • Xiaowei Liu
  • Eric Frey
  • Yuni Dewaraja
  • Sven-Erik Strand
Publishing year: 2002
Language: English
Pages: 1101-1109
Publication/Series: Journal of Nuclear Medicine
Volume: 43
Issue: 8
Document type: Journal article
Publisher: Society of Nuclear Medicine

Abstract english

A general method is presented for patient-specific 3-dimensional absorbed dose calculations based on quantitative SPECT activity measurements. METHODS: The computational scheme includes a method for registration of the CT image to the SPECT image and position-dependent compensation for attenuation, scatter, and collimator detector response performed as part of an iterative reconstruction method. A method for conversion of the measured activity distribution to a 3-dimensional absorbed dose distribution, based on the EGS4 (electron-gamma shower, version 4) Monte Carlo code, is also included. The accuracy of the activity quantification and the absorbed dose calculation is evaluated on the basis of realistic Monte Carlo-simulated SPECT data, using the SIMIND (simulation of imaging nuclear detectors) program and a voxel-based computer phantom. CT images are obtained from the computer phantom, and realistic patient movements are added relative to the SPECT image. The SPECT-based activity concentration and absorbed dose distributions are compared with the true ones. RESULTS: Correction could be made for object scatter, photon attenuation, and scatter penetration in the collimator. However, inaccuracies were imposed by the limited spatial resolution of the SPECT system, for which the collimator response correction did not fully compensate. CONCLUSION: The presented method includes compensation for most parameters degrading the quantitative image information. The compensation methods are based on physical models and therefore are generally applicable to other radionuclides. The proposed evaluation methodology may be used as a basis for future intercomparison of different methods.


  • Radiology, Nuclear Medicine and Medical Imaging
  • Non-U.S. Gov't
  • Radiotherapy Dosage
  • Imaging
  • Phantoms
  • Monte Carlo Method
  • Iodine Radioisotopes : therapeutic use
  • Computer-Assisted
  • Image Processing
  • Human
  • Support
  • Single-Photon
  • P.H.S.
  • U.S. Gov't
  • Tomography
  • Emission-Computed


  • ISSN: 0161-5505
Sven-Erik Strand
E-mail: sven-erik [dot] strand [at] med [dot] lu [dot] se

Project manager

Systemic Radiation Therapy Group


Professor emeritus

Medical Radiation Physics, Lund