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Radiolabeled antibodies in prostate cancer: A case study showing the effect of host immunity on antibody bio-distribution.

Author:
  • Oskar Vilhelmsson Timmermand
  • Elmer Santos
  • Daniel L J Thorek
  • Susan Evans Axelsson
  • Anders Bjartell
  • Hans Lilja
  • Steven M Larson
  • Sven-Erik Strand
  • Thuy Tran
  • David Ulmert
Publishing year: 2015
Language: English
Pages: 375-380
Publication/Series: Nuclear Medicine and Biology
Volume: 42
Issue: 4
Document type: Journal article
Publisher: Elsevier

Abstract english

Human tumors xenografted in immunodeficient mice are crucial models in nuclear medicine to evaluate the effectiveness of candidate diagnostic and therapeutic compounds. However, little attention has been focused on the biological profile of the host model and its potential effects on the bio-distribution and tumor targeting of the tracer compound under study. We specifically investigated the dissimilarity in bio-distribution of (111)In-DTPA-5A10, which targets free prostate specific antigen (fPSA), in two animal models.

Keywords

  • Radiology, Nuclear Medicine and Medical Imaging

Other

Published
  • Urological cancer, Malmö
  • Clinical Chemistry, Malmö
  • ISSN: 1872-9614
Sven-Erik Strand
E-mail: sven-erik [dot] strand [at] med [dot] lu [dot] se

Project manager

Systemic Radiation Therapy Group

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Professor emeritus

Medical Radiation Physics, Lund

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