The Intratumoral Distribution of Radiolabeled 177Lu-BR96 Monoclonal Antibodies Changes in Relation to Tumor Histology over Time in a Syngeneic Rat Colon Carcinoma Model.
- Medical Radiation Physics, Lund
- Oncology and Pathology, MV
Publishing year: 2013
Publication/Series: Journal of Nuclear Medicine
Document type: Journal article
Publisher: Society of Nuclear Medicine
The therapeutic effect of radioimmunotherapy depends on the distribution of the absorbed dose in relation to viable cancer cells within the tumor, which in turn is a function of the activity distribution. The aim of this study was to investigate the distribution of (177)Lu-DOTA-BR96 monoclonal antibodies targeting the Lewis Y antigen over 7 d using a syngeneic rat model of colon carcinoma.
- Radiology, Nuclear Medicine and Medical Imaging
- ISSN: 0161-5505