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The Intratumoral Distribution of Radiolabeled 177Lu-BR96 Monoclonal Antibodies Changes in Relation to Tumor Histology over Time in a Syngeneic Rat Colon Carcinoma Model.

Author:
  • Anders Örbom
  • Sophie Eriksson
  • Erika Elgström
  • Tomas G Ohlsson
  • Rune Nilsson
  • Jan Tennvall
  • Sven-Erik Strand
Publishing year: 2013
Language: English
Pages: 1404-1410
Publication/Series: Journal of Nuclear Medicine
Volume: 54
Issue: 8
Document type: Journal article
Publisher: Society of Nuclear Medicine

Abstract english

The therapeutic effect of radioimmunotherapy depends on the distribution of the absorbed dose in relation to viable cancer cells within the tumor, which in turn is a function of the activity distribution. The aim of this study was to investigate the distribution of (177)Lu-DOTA-BR96 monoclonal antibodies targeting the Lewis Y antigen over 7 d using a syngeneic rat model of colon carcinoma.

Keywords

  • Radiology, Nuclear Medicine and Medical Imaging

Other

Published
  • ISSN: 0161-5505
Sven-Erik Strand
E-mail: sven-erik [dot] strand [at] med [dot] lu [dot] se

Project manager

Systemic Radiation Therapy Group

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Professor emeritus

Medical Radiation Physics, Lund

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