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Optimizing retention of multimodal imaging nanostructures in sentinel lymph nodes by nanoscale size tailoring.

Author:
  • Pontus Kjellman
  • René in 't Zandt
  • Sarah Fredriksson
  • Sven-Erik Strand
Publishing year: 2014
Language: English
Pages: 1089-1095
Publication/Series: Nanomedicine: Nanotechnology, Biology and Medicine
Volume: 10
Issue: 5
Document type: Journal article
Publisher: Elsevier

Abstract english

This study investigates the retention of different sized ultra-small superparamagnetic iron oxide nanoparticles (USPIOs) in lymph nodes of healthy rats, after subcutaneous injection. Three distinct sizes (15, 27 and 58 nm) of USPIOs were synthesized by only varying the thickness of the polymer coating surrounding the 10 nm cores. Particles were injected on the dorsal side of the hind paw of rats and the uptake in the popliteal, inguinal and iliac lymph nodes was monitored. The data reveal that the 15 nm particle accumulates more rapidly and to a higher amount in the first lymph node than the two larger particles. A clear contrast between the first and second lymph nodes could be detected indicating that even the rather small difference in particle size (15-58 nm) tested has significant effects on the retention of USPIOs in the lymph nodes.

Keywords

  • Radiology, Nuclear Medicine and Medical Imaging

Other

Published
  • ISSN: 1549-9642
Sven-Erik Strand
E-mail: sven-erik [dot] strand [at] med [dot] lu [dot] se

Project manager

Systemic Radiation Therapy Group

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Professor emeritus

Medical Radiation Physics, Lund

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