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Changes in glycoprotein expression between primary breast tumour and synchronous lymph node metastases or asynchronous distant metastases.

Author:
  • Emila Kurbasic
  • Martin Sjöström
  • Morten Krogh
  • Elin Folkesson
  • Dorthe Grabau
  • Karin M Hansson
  • Lisa Rydén
  • Sofia Waldemarson
  • Peter James
  • Emma Niméus
Publishing year: 2015
Language: English
Publication/Series: Clinical Proteomics
Volume: 12
Issue: 1
Document type: Journal article
Publisher: Humana Press

Abstract english

Breast cancer is a very heterogeneous disease and some patients are cured by the surgical removal of the primary tumour whilst other patients suffer from metastasis and spreading of the disease, despite adjuvant therapy. A number of prognostic and treatment predictive factors have been identified such as tumour size, oestrogen (ER) and progesterone (PgR) receptor status, human epidermal growth factor receptor type 2 (HER2) status, histological grade, Ki67 and age. Lymph node involvement is also assessed during surgery to determine if the tumour has spread which requires dissection of the axilla and adjuvant treatment. The prognostic and treatment predictive factors assessing the nature of the tumour are all routinely based on the status of the primary tumour.

Keywords

  • Cancer and Oncology

Other

Published
  • CREATE Health
  • Breast cancer Proteogenomics
  • ISSN: 1559-0275
Peter James
E-mail: peter [dot] james [at] immun [dot] lth [dot] se

Professor

Department of Immunotechnology

+46 46 222 14 96

+46 70 247 79 60

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