Changes in glycoprotein expression between primary breast tumour and synchronous lymph node metastases or asynchronous distant metastases.

Summary, in English

Breast cancer is a very heterogeneous disease and some patients are cured by the surgical removal of the primary tumour whilst other patients suffer from metastasis and spreading of the disease, despite adjuvant therapy. A number of prognostic and treatment predictive factors have been identified such as tumour size, oestrogen (ER) and progesterone (PgR) receptor status, human epidermal growth factor receptor type 2 (HER2) status, histological grade, Ki67 and age. Lymph node involvement is also assessed during surgery to determine if the tumour has spread which requires dissection of the axilla and adjuvant treatment. The prognostic and treatment predictive factors assessing the nature of the tumour are all routinely based on the status of the primary tumour.

• Author: Emila Kurbasic; Martin Sjöström; Morten Krogh; Elin Folkesson; Dorthe Grabau; Karin M Hansson; Lisa Rydén; Sofia Waldemarson; Peter James; Emma Niméus
• Department/s: Breast cancer Proteogenomics; Department of Immunotechnology; Breastcancer-genetics; Rheumatology; Tumor microenvironment; Surgery (Lund); BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2015
• Language: English
• Publication/Series: Clinical Proteomics
• Volume: 12
• Issue: 1
• Full text: - 4 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25991917?dopt=Abstract; http://dx.doi.org/10.1186/s12014-015-9084-7
• Document type: Journal article
• Publisher: Humana Press
• Topic: Cancer and Oncology
• Status: Published
• Research group: Breast cancer Proteogenomics
• ISBN/ISSN/Other: ISSN: 1559-0275