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The enhanced contractility of the phospholamban-deficient mouse heart persists with aging

Author:
  • J. P. Slack
  • I. L. Grupp
  • R. Dash
  • D. Holder
  • A. Schmidt
  • M. J. Gerst
  • T. Tamura
  • C. Tilgmann
  • P. F. James
  • R. Johnson
  • A. M. Gerdes
  • E. G. Kranias
Publishing year: 2001
Language: English
Pages: 1031-1040
Publication/Series: Journal of Molecular and Cellular Cardiology
Volume: 33
Issue: 5
Document type: Journal article
Publisher: Elsevier

Abstract english

Phospholamban ablation in the mouse is associated with significant increases in cardiac contractility. To determine whether this hyperdynamic function persists through the aging process, a longitudinal examination of age-matched phospholamban-deficient and wild-type mice was employed. Kaplan-Meier survival curves indicated no significant differences between phospholamban-deficient and wild-type mice over the first year. Examination of cardiac function revealed significant increases in the rates of contraction (+dP/dt) and relaxation (-dP/dt) in phospholamban-deficient hearts compared with their wild-type counterparts at 3, 6, 12, 18 and 24 months of age. Quantitative immunoblotting indicated that the expression levels of the sarcoplasmic reticulum Ca2+-ATPase were not altered in wild-type hearts, while they were significantly decreased at 12 months (40%) and 18 months (20%) in phospholamban-deficient hearts. These findings on the persistence of hyperdynamic cardiac function over the long terra suggest that phospholamban may constitute an important target for treatment in heart disease.

Keywords

  • Aging
  • Contractility
  • Myocardium
  • Phospholamban
  • Sarcoplasmic reticulum

Other

Published
  • ISSN: 0022-2828
Peter James
E-mail: peter [dot] james [at] immun [dot] lth [dot] se

Professor

Department of Immunotechnology

+46 46 222 14 96

+46 70 247 79 60

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