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Cylindrocyclin A, a new cytotoxic cyclopeptide from Cylindrocarpon sp.

  • Daniela Weber
  • Gilda Erosa
  • Olov Sterner
  • Timm Anke
Publishing year: 2006
Language: English
Pages: 495-499
Publication/Series: Journal of Antibiotics
Volume: 59
Issue: 8
Document type: Journal article
Publisher: Japan Antibiotics Research Association

Abstract english

In the course of a screening of fungal extracts for new metabolites with cytotoxic activities cylindrocyclin A (1) was isolated. The producing strain was identified as Cylindrocarpon sp. by microscopy and ITS rDNA sequence analysis. 1 is a novel compound that exhibits cytotoxic acticity against six different cell lines with IC50 values ranging from 11 to 53 mu M. 1 has no antibacterial or antifungal activity. The compound is a cyclic nonapeptide comprising three alanines, five leucines and one isoleucine. Four amino acids are N-methylated. Its structure was elucidated by spectroscopic methods.


  • Organic Chemistry
  • cylindrocarpon
  • cytotoxic
  • new metabolite
  • cyclopeptide


  • ISSN: 0021-8820
Olov Sterner
E-mail: olov [dot] sterner [at] chem [dot] lu [dot] se


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