Menu

Javascript is not activated in your browser. This website needs javascript activated to work properly.
You are here

Multiple Anticancer Effects of Damsin and Coronopilin Isolated from Ambrosia arborescens on Cell Cultures.

Author:
  • Rodrigo Villagomez
  • Gloria Rodrigo
  • Isidro G Collado
  • Marco A Calzado
  • Eduardo Muñoz
  • Björn Åkesson
  • Olov Sterner
  • Giovanna R Almanza
  • Rui-Dong Duan
Publishing year: 2013
Language: English
Pages: 3799-3805
Publication/Series: Anticancer Research
Volume: 33
Issue: 9
Document type: Journal article
Publisher: International Institute of Cancer Research

Abstract english

Terpenoids in plants are important sources for drug discovery. In this study, we extracted damsin and coronopilin, two sesquiterpene lactones, from Ambrosia arborescens and examined their anticancer effects on cell cultures. Damsin and coronopilin inhibited cell proliferation, DNA biosynthesis and formation of cytoplasmic DNA histone complexes in Caco-2 cells, with damsin being more potent than coronopilin. Further studies using the luciferase reporter system showed that damsin and coronopilin also inhibited expressions of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription-3 (STAT3), indicating that these sesquiterpenes can interfere with NF-κB and STAT3 pathways. Finally, we examined the effects of two synthetic dibrominated derivatives of damsin, 11α,13-dibromodamsin and 11β,13-dibromodamsin. While bromination appeared to weaken the antiproliferative effects of damsin, the β epimer had strong inhibitory effects on STAT3 activation. In conclusion, the sesquiterpene lactones damsin and coronopilin have inhibitory effects on cell proliferation, DNA biosynthesis and NF-κB and STAT3 pathways, thus being potentially important for discovery of drugs against cancer.

Keywords

  • Cancer and Oncology

Other

Published
  • ISSN: 1791-7530
Olov Sterner
E-mail: olov [dot] sterner [at] science [dot] lu [dot] se

Dean

Faculty of Science

+46 46 222 82 13

+46 70 530 66 49

B127

Sölvegatan 27, Lund

39

Professor

Centre for Analysis and Synthesis

+46 46 222 82 13

1