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Phomol, a new antiinflammatory metabolite from an endophyte of the medicinal plant Erythrina crista-galli

Author:
  • D Weber
  • Olov Sterner
  • T Anke
  • S Gorzalczancy
  • V Martino
  • C Acevedo
Publishing year: 2004
Language: English
Pages: 559-563
Publication/Series: Journal of Antibiotics
Volume: 57
Issue: 9
Document type: Journal article
Publisher: Japan Antibiotics Research Association

Abstract english

Phomol (1), a novel antibiotic, was isolated from fermentations of a Phomopsis species in the course of a screening of endophytic fungi from the medicinal plant Erythrina crista-galli. For this Argentinean leguminosa anti inflammatory and neuroleptic activities have been described. The compound exhibits antifungal, antibacterial and weak cytotoxic acticity. The anti inflammatory activity was tested in different reporter gene assays (TNF-alpha, STAT1/STAT2 and NF-kappaB) and in an ear edema model in mice. In the reporter gene assays I exhibited no activity, whereas I showed interesting antiinflammatory activity in the mouse ear assay. The compound is a polyketide lactone and its structure was elucidated by spectroscopic methods.

Keywords

  • Organic Chemistry

Other

Published
  • ISSN: 0021-8820
Olov Sterner
E-mail: olov [dot] sterner [at] science [dot] lu [dot] se

Dean

Faculty of Science

+46 46 222 82 13

+46 70 530 66 49

B127

Sölvegatan 27, Lund

39

Professor

Centre for Analysis and Synthesis

+46 46 222 82 13

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