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Antileishmanial metabolites from Lantana balansae

  • Eliana M. Maldonado
  • Efrain Salamanca
  • Alberto Giménez
  • Olov Sterner
Publishing year: 2016-01-01
Language: English
Pages: 180-183
Publication/Series: Brazilian Journal of Pharmacognosy
Volume: 26
Issue: 2
Document type: Journal article
Publisher: Sociedade Brasileira de Farmacognosia

Abstract english

Eleven compounds, 12-oxo-phytodienoic acid (1), persicogenin (2), eriodictyol 3ʹ4ʹ,7-trimethyl ether (3), phytol (4), spathulenol (5), 4-hydroxycinnamic acid (6), onopordin (7), 5,8,4ʹ-trihydroxy-7,3ʹ-dimethoxyflavone (8), quercetin (9), jaceosidin (10), and 8-hydroxyluteolin (11), were isolated from an ethanol extract of Lantana balansae Briq., Verbenaceae, that was found to possess antileishmanial activ-ity. The structures of the compounds were determined by NMR spectroscopy and HR mass spectrometry, and 1, 2, 3, 7, 8 and 9 were investigated for antiprotozoal activity toward promastigotes of Leishmania amazonensis and Leishmania braziliensis. Compound 1 was shown to be the most potent, with the IC50 values 2.0µM toward L. amazonensis and 0.68µM toward L. braziliensis, although less potent than the positive control Amphotericin B. All compounds have been reported previously, but this is the first report of the isolation of a cyclopentenone fatty acid (1) and flavanones (2 and 3) from a Lantana species.


  • Pharmaceutical Sciences
  • 12-oxo-phytodienoic acid
  • Flavonoids
  • L. braziliensis
  • Lantana balansae
  • Leishmania amazonensis


  • ISSN: 0102-695X
Olov Sterner
E-mail: olov [dot] sterner [at] science [dot] lu [dot] se


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