A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).
- Centre for Analysis and Synthesis
Publishing year: 2003
Publication/Series: Journal of Natural Products
Document type: Journal article
Publisher: The American Chemical Society
The macrocyclic lathyrane polyester Euphorbia factor L10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris). The interaction of L10 (1a) and its acetyl derivative (1b) with P-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. The results established lathyrane diterpenoids as a novel chemotype for P-glycoprotein inhibitors.
- Organic Chemistry
- ISSN: 0163-3864