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Synthesis of (-)-pregaliellalactone, conversion of (-)-pregaliellalactone to (-)-galiellalactone by mycelia of Galiella rufa

Author:
  • Martin H Johansson
  • B Kopcke
  • H Anke
  • Olov Sterner
Publishing year: 2002
Language: English
Pages: 2523-2528
Publication/Series: Tetrahedron
Volume: 58
Issue: 13
Document type: Journal article
Publisher: Elsevier

Abstract english

An enantioselective synthesis of (-)-pregaliellalactone (1), a biosynthetic precursor of the potent fungal metabolite ( -)-galiellalactone (3) produced by several ascomycetes, is reported. When fed to a culture of Galiella rufa, 1 was efficiently converted to 3. (C) 2002 Elsevier Science Ltd. All rights reserved.

Keywords

  • Organic Chemistry
  • pregaliellalactone
  • stannylation
  • Diels-Alder cyclisation
  • Galiella rufa
  • galiellalactone

Other

Published
  • ISSN: 0040-4020
Olov Sterner
E-mail: olov [dot] sterner [at] science [dot] lu [dot] se

Dean

Faculty of Science

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Professor

Centre for Analysis and Synthesis

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