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Synthesis of C-1 indol-3-yl substituted tetrahydroisoquinoline derivatives via a Pictet-Spengler approach

Author:
  • Rikard Larsson
  • Narda Blanco
  • Martin H Johansson
  • Olov Sterner
Publishing year: 2012
Language: English
Pages: 4966-4970
Publication/Series: Tetrahedron Letters
Volume: 53
Issue: 37
Document type: Journal article
Publisher: Elsevier

Abstract english

A protocol for the diastereoselective synthesis of C-1 indol-3-yl substituted tetrahydroisoquinoline derivatives via Pictet-Spengler condensation with L-DOPA or L-DOPA derivatives and 1H-indole-3-carbaldehydes is presented. The protocol is used for the successful synthesis of several tetrahydroisoquinolines as well as diketopiperazine fused analogues. (C) 2012 Elsevier Ltd. All rights reserved.

Keywords

  • Chemical Sciences
  • Pictet-Spengler condensation
  • L-DOPA
  • 1H-Indole-3-carbaldehydes
  • C-1
  • Indolyl tetrahydroisoquinolines
  • Diketopiperazine fused
  • tetrahydroisoquinolines

Other

Published
  • ISSN: 0040-4039
Olov Sterner
E-mail: olov [dot] sterner [at] science [dot] lu [dot] se

Dean

Faculty of Science

+46 46 222 82 13

+46 70 530 66 49

B127

Sölvegatan 27, Lund

39

Professor

Centre for Analysis and Synthesis

+46 46 222 82 13

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