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Dacrymenone and VM 3298-2 - New antibiotics with antibacterial and antifungal activity

Author:
  • V Mierau
  • T Anke
  • Olov Sterner
Publishing year: 2003
Language: English
Pages: 541-546
Publication/Series: Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences
Volume: 58
Issue: 7-8
Document type: Journal article
Publisher: Verlag der Zeitschrift für Naturforschung

Abstract english

Two new antibiotic metabolites, dacrymenone (1) and VM 3298-2 (2), were isolated from fermentations of a Dacrymyces sp., and their structures were determined by spectroscopic techniques. Dacrymenone (1) is a new eremophilane sesquiterpenoid while VM 3298-2 (2) is a bis-enol ether between methyl pyruvate and 4,6-dihydroxycyclohexan-1,3-dione. Dacrymenone (1) shows weak antibacterial and antifungal activity while VM 3298-2 (2) exhibits cytotoxic and antifungal activities.

Keywords

  • Organic Chemistry
  • antifungal antibiotic
  • eremophilanes
  • Dacrymyces

Other

Published
  • ISSN: 0939-5075
Olov Sterner
E-mail: olov [dot] sterner [at] science [dot] lu [dot] se

Dean

Faculty of Science

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Professor

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