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Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia

Author:
  • Maria Andersson
  • Ola Bergendorff
  • Mogens Nielsen
  • Olov Sterner
  • Robin Witt
  • Jinglu Ai
  • Aiping Lu
  • An Min Wang
Publishing year: 1995
Language: English
Pages: 835-836
Publication/Series: Phytochemistry
Volume: 38
Issue: 4
Document type: Journal article
Publisher: Elsevier

Abstract english

S-(4-hydroxybenzyl)glutathione was isolated as the major principle responsible for the inhibition of the in vitro binding of kainic acid to brain glutamate receptors by water extracts of the plant Gastrodia elata. The affinity (IC50 value) of the compound is slightly lower compared to glutamate and glutathione.

Keywords

  • Dermatology and Venereal Diseases

Other

Published
  • ISSN: 0031-9422
Olov Sterner
E-mail: olov [dot] sterner [at] science [dot] lu [dot] se

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