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Base-catalyzed intramolecular condensation of tokinolide B.

Author:
  • B Quiroz-García
  • L Hernández
  • R A Toscano
  • Olov Sterner
  • G Delgado
Publishing year: 2003
Language: English
Pages: 2509-2512
Publication/Series: Tetrahedron Letters
Volume: 44
Issue: 12
Document type: Journal article
Publisher: Elsevier

Abstract english

The novel pentacyclic compound cyclotokinolide B was obtained from the natural phthalide tokinolide B under basic conditions, via the chemoselective -enol lactone opening followed by a Michael addition of the generated carbanion to the enone and subsequent equilibration. This result confirms that some dimeric phthalides undergo intramolecular cyclizations in basic media.

Keywords

  • Organic Chemistry

Other

Published
  • ISSN: 0040-4039
Olov Sterner
E-mail: olov [dot] sterner [at] science [dot] lu [dot] se

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Professor

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