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SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis

Author:
  • G Appendino
  • S Prosperini
  • Carola Valdivia
  • M Ballero
  • G Colombano
  • R A Billington
  • A A Genazzani
  • Olov Sterner
Publishing year: 2005
Language: English
Pages: 1213-1217
Publication/Series: Journal of Natural Products
Volume: 68
Issue: 8
Document type: Journal article
Publisher: The American Chemical Society

Abstract english

An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.

Keywords

  • Organic Chemistry

Other

Published
  • ISSN: 0163-3864
Olov Sterner
E-mail: olov [dot] sterner [at] science [dot] lu [dot] se

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